Application of 147149-84-6,Some common heterocyclic compound, 147149-84-6, name is 4-Bromo-5-methylindoline-2,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a microwave reaction tube were added indoles (2 mmol), isatins (1 mmol) and HFIP (2 mL). After sealing the tube, the mixture was heated to 75C in an oil bath and stirred for 1 h. After completion of the reaction (monitored by TLC), the reaction mixture was cooled to room temperature, and the resulting precipitate was then filtered, washed with ether, and dried to give compound 3a-3q and 4a-4j.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-5-methylindoline-2,3-dione, its application will become more common.
Reference:
Article; Cheng, Jialing; Liu, Hong-Min; Wang, Shuai; Yu, Bin; Yuan, Xiaohan; Chinese Chemical Letters; (2020);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem