Synthetic Route of 222036-66-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 222036-66-0, name is 5-Aminoisoindolin-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Synthesis of 5-((5-oxo-2,5-dihydro-1H-pyrrol-3-yl)amino)isoindolin-1-one (Cpd. No. 9) A mixture of pyrrolidine-2,4-dione (1, 18 mg, 0.18 mmol) and 5-aminoisoindolin-1-one (2, 27 mg, 0.18 mmol) in methanol (1 mL) was stirred at 60¡ã C. for 1 h. Upon cooling, the mixture was filtered, followed by rinsing with methanol. The solid was dried under vacuum to afford 5-((5-oxo-2,5-dihydro-1H-pyrrol-3-yl)amino)isoindolin-1-one (Cpd. No. 9) as an off-white solid. Yield: 23 mg, 55percent; 1H NMR (300 MHz, DMSO-d6) delta 9.44 (s, 1H), 8.28 (s, 1H), 7.57 (d, J=4.8 Hz, 1H), 7.32 (s, 1H), 7.19 (s, 1H), 7.15 (dd, J=1.2, 5.1 Hz, 1H), 5.40 (s, 1H), 4.32 (s, 2H), 4.01 (s, 2H).
The synthetic route of 5-Aminoisoindolin-1-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; eFFECTOR Therapeutics, Inc.; Sprengeler, Paul A.; Reich, Siegfried H.; Ernst, Justin T.; Webber, Stephen E.; Shaghafi, Mike; Murphy, Douglas; Tran, Chinh; (131 pag.)US10112955; (2018); B2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem