Adding a certain compound to certain chemical reactions, such as: 59-48-3, name is Indolin-2-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59-48-3, Formula: C8H7NO
Concentrated nitric acid (9.31 g, 0.096 mol) was added in drops over 60 min and at 0 C. to a solution of indolin-2-one (13.3 g, 0.100 mol) in concentrated sulfuric acid (67 mL), and the resultant dark-brown solution was then stirred at this temperature for 1 h. The reaction mixture was then poured over ice and sucked away. The residue was washed again with water and dried, then recrystallized from isopropanol. 5-nitroindolin-2-one in the form of golden, shiny sheets was obtained (12.28 g, 69%). fp: >300 C. 1HNMR (300 MHz, d6-DMSO): delta=3.61 (s, 2H, H2), 6.97 (d, 1H, H7), 8.05 (d, 1H, H6), 8.05 (s, 1H, H4), 8.15 (d, 1H, H6), 11.03 (bs, 1H, NH). 13C NMR (100 MHz, DMSO): 35.9 (C2), 109.2 (C7), 120.3 (C4), 125.1 (C6), 127.2 (C9), 142.0 (C5), 150.6 (C8), 177.0 (C2)
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Reference:
Patent; Henkel AG & Co. KGaA; Gebert-Schwarzwaelder, Antje; Giesa, Helmut; Schoenebeck, Jan-Michael; (23 pag.)US2017/165166; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem