These common heterocyclic compound, 14192-26-8, name is Methyl 2-oxoindoline-6-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 14192-26-8
To a solution of methyl 2-oxoindoline-6-carboxylate (17.6 g) in DMF (260 ml) was added Mel (26.1 g) followed by NaH (3.68 g) keeping the temperature at 22 C. After 30 min a second portion of NaH (1.84 g) was added followed after 1 h by a third portion (1.84 g) and stirring was continued at 22 C for 16 h. Water (7 ml) followed by sodium hydroxide (34.5 g) were added and stirring was continued at 45 C for 1 h and at 22 C for 16 h. The mixture was partitioned between TBME and water, the pH of the aqueous layer was adjusted to 3 using aqueous hydrochloric acid (25%) and extracted with dichloromethane. The organic layere was dried and evaporated to give the crude title compound (17.9 g, 95%) as a red solid, which was used without further purification. MS (ESI, m/z): 204.2 [(M-H)”].
The synthetic route of Methyl 2-oxoindoline-6-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HILPERT, Hans; KOLCZEWSKI, Sabine; LIMBERG, Anja; STOLL, Theodor; WO2015/177110; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem