Electric Literature of 3783-77-5, The chemical industry reduces the impact on the environment during synthesis 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione, I believe this compound will play a more active role in future production and life.
To a solution of tert-butyl [(2R)-l-(aminooxy)-3-methylbutan-2-yl]carbamate (5.0 gm, 23.04 mmol) in pyridine (50 ml) was added N-(3-oxo-butyl)-pthalamide (5.0 gm, 23.04 mmol) under stirring at 30C. The reaction mixture was stirred at 30C for 12 hours. After completion of the reaction, solvent was evaporated under vacuum and the residue obtained was dissolved in ethyl acetate (200 ml). The ethyl acetate layer was washed with saturated aqueous ammonium chloride solution, water and brine solution. Layers were separated and organic layer was dried over sodium sulphate. Evaporation of solvent provided crude mass, which was purified by triturating with diethyl ether to provide 6.1 gm of 2-[(3E/Z)-3-({ [(2R)- 2-(tert-butoxycarbonyl)amino-3-methylbutyl]oxy}imino)butyl]-lH-isoindole-l,3(2H)-dione as a colourless oil (63% yield). Analysis: Mass (M+l): ES: 418.3 for C22H31N3O5; 1H NMR (400 MHz, CDC13): delta 7.83-7.88 (m, 2H), 7.70-7.73 (m, 2H), 4.67-4.70 (br s, 1H), 3.84-3.98 (m, 2H), 2.65-2.89 (m, 2H), 2.53 (ddd, 1H), 1.91 (d, 3H), 1.70-1.77 (m, 1H), 1.43 (s, 9H), 0.84-0.90 (m, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3-Oxobutyl)isoindoline-1,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; WOCKHARDT LIMITED; CHAVAN, Vijay Prakash; BHAVSAR, Satish; PAVASE, Laxmikant; GUPTA, Sunil; MISHRA, Amit; KALE, Rajesh; JOSHI, Sanjeev; DABHADE, Sanjay Kisan; JADHAV, Sunil Bhaginath; KAYASTHA, Abhijeet Kantilal; PAWAR, Shivaji Sampatrao; RANE, Vipul Prabhakar; AHIRRAO, Vinod Kashinath; YEOLE, Ravindra Dattatraya; DESHPANDE, Prasad Keshav; BHAGWAT, Sachin Subhash; PATEL, Mahesh Vithalbhai; (50 pag.)WO2018/203197; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem