Reference of 104618-32-8,Some common heterocyclic compound, 104618-32-8, name is 2-(4-Oxocyclohexyl)isoindoline-1,3-dione, molecular formula is C14H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(B) 15gm (0.0617mole) 4-phthalimido cyclohexanone was dissolve in 150ml Ethylacetate. Cool the mass to 0C. Add Br2 solution (9.8gm Bra in 25ml of methanol) and0.25gm of Aids under stirring. Stop stirring and allow initiating bromination and findingclear solution then add remaining quantity of Br2 solution and stir for 10-15mins. Washthe reaction mass with 75ml 2% NaS2O3 solution then wash organic phase with 75ml8%NaHCO3. Then in last wash it with brine solution. Collect organic masses andevaporate it under vacuum. Dry it at 50C for 2-3hrs.YIELD: 15gms(75.2%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Oxocyclohexyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Patent; ALEMBIC LIMITED; WO2006/3677; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem