Reference of 118289-55-7,Some common heterocyclic compound, 118289-55-7, name is 6-Chloro-5-(2-chloroethyl)indolin-2-one, molecular formula is C10H9Cl2NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
500 g of 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride of the formula I compound was added to 5 L of acetonitrile, then 422 g of potassium carbonate was added, and after stirring for 30 minutes, 450 g of 5-(2-chloroethyl)-6-chloro-1,3-dihydro-fluorenone was subsequently added thereto and 10 g of sodium iodide, heated to reflux, and warmed to completion. The solvent was removed under reduced pressure. 2L of deionized water was added and the mixture was stirred for 2 hours. The filter cake was rinsed with 500 ml of deionized water, and the filter cake was dried to obtain crude ziprasidone IV767g in a yield of 95.1%. The crude product was 99.5% pure and 1,4-bis(benzo[d]isothiazole-3- The base) piperazine (VI) has a content of less than 0.05%, and this reaction is carried out by commercially available formula I to obtain ziprasidone IV of the type having a yield of 90% and a purity of 98.8%, wherein 1,4-bis(benzo[d]isothiazol-3-yl)piperazine The content of formula (VI) is more than 0.15%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Chloro-5-(2-chloroethyl)indolin-2-one, its application will become more common.
Reference:
Patent; Shanghai Tianci Biological Gu Biological Engineering Co., Ltd.; Li Xinjuanzi; Li Jianzhi; Wang Xun; Li Yonggang; Shen Xiaoliang; Gao Yan; Lv Xinghong; (14 pag.)CN104370850; (2018); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem