Related Products of 52351-75-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52351-75-4 name is 6-Methoxyindoline-2,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate- 136: 6-Methoxy-l-methylindoline-2, 3-dione:To a stirred suspension of commercially available 6-methoxyindoline-2,3-dione (0.2 g ,1.12 mmol) and sodium hydride (60% w/w dispersion in mineral oil, 0.067 g,2.79 mmol) in dry DMF ( 5 ml) was added methyl iodide (0.084 ml, 1.35 mmol) slowly at 0 C. The mixture was stirred at 0 C for 45 min and quenched with water (10 ml) at 0 C and added ethyl acetate. The two phases were separated and the aqueous phase was extracted with ethyl acetate (2x 25 ml). The combined organic layer was washed with water (2×20 ml), followed by brine (2×20 ml), dried over sodium sulfate and filtered. The filtrate was concentrated in vacuum to dryness to get a brown solid of 6-methoxy-l-methylindoline-2, 3-dione (0.140 g, 65%). 1H NMR (400 MHz, CDC13) delta 7.58 (d, J = 8 Hz, 1H), 6.57 (dd, J = 8 Hz, 4 Hz, 1H), 6.36 (d, J = 4 Hz, 1H), 3.93 (s, 3H), 3.22 (s, 3H); MS (ES+) m/z 191.9 (M+l), 213.9 (M+ Na)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Methoxyindoline-2,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; LUPIN LIMITED; PADIYA, Kamlesh, Jyotindra; NAIR, Prathap, S.; PAL, Ravindra, Ramsurat; CHAURE, Ganesh, Shankar; GUDADE, Ganesh, Bhausaheb; PARKALE, Santosh, Sadashiv; MANOJKUMAR, Vishwanath, Lohar; SWAPNIL, Ramesh, Bajare; SMITA, Aditya, Bhoskar; SACHIN, Dilip, Survase; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2012/49555; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem