In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2058-72-2 as follows. 2058-72-2
General procedure: solution of isatin (1a) (0.3 gm, 2.04 mmol),proline (2) (0.234 gm, 2.04 mmol) and methyl vinyl ketone (3) (255 muL, 3.00 mmol) in CH3CNwas heated to 80 C for 2 h. After the completion of starting precursor, the reaction mixture wascooled and solvent was evaporated on rotator evaporator to provide brown solid. The reactionmixture was purified by silica gel chromatography using hexane:ethyl acetate (6:4) as an eluentto provide product (4a) as a white solid
According to the analysis of related databases, 2058-72-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Tiwari, Keshri Nath; Pandurang, Taur Prakash; Pant, Suyash; Sreelekha; Synthetic Communications; vol. 48; 7; (2018); p. 802 – 808;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem