The chemical industry reduces the impact on the environment during synthesis 143262-20-8, name is 1-(tert-Butoxycarbonyl)indoline-7-carboxylic acid, I believe this compound will play a more active role in future production and life. 143262-20-8
Step 3: Methyl 4-{ l-[(2,3-dihydro-lH-indol-7-ylcarbonyl)amino]cyclopropyl}benzoatel-(te^butoxycarbonyl)indoline-7-carboxylic acid (300 mg, 1.14 mmol), HATU (475 mg, 21.2 mmol) and methyl 4-(l-aminocyclopropyl)benzoate (262 mg, 1.37 mmol) were added to acetonitrile (7.6 ml). The solution was cooled in an ice bath and DIPEA (695 ul, 3.99 mmol) was added. After 2 hr at RT, the mixture was poured into a solution OfNaHCO3 (l/2sat.) and washed 3 times with EtOAc. The combined organic layers were washed with brine and dried with Na2SO4. The solvent was removed and the crude mixture purified by flash chromatography on silica gel. The Boc group was removed with 1:1 TFA/DCM using the standard procedure.
The chemical industry reduces the impact on the environment during synthesis 143262-20-8. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2008/104055; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem