Some scientific research about 3485-84-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3485-84-5, other downstream synthetic routes, hurry up and to see.

A common compound: 3485-84-5, name is N-Vinylphthalimide, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 3485-84-5

A solution of the hydrazone 11.40 (2.5 g, 7.1 mmol) in anhydrous THF (60 mL) is cooled to – 78 0C and 1 M sodium hexamethyldisilazane (7.1 mL, 7.1 mmol) is added. The mixture is maintained at -78 0C for 15 min. then allowed to warm to room temperature. The solvent is removed under vacuum leaving a light yellow residue which is suspended in 1 ,4-dioxane (100 mL). To the suspension is added N-vinylphthalimide (7.3 g, 42.1 mmol), benzyltriethylammonium chloride (0.20 g, 0.88 mmol), and rhodium diacetate dimer (38 mg, 0.086 mmol). The resulting mixture is heated to 50 0C for 48 h. EtOAc (200 mL) is added and the mixture is washed with water (4 x 100 mL). The organic layer is separated, dried over Na2SO4, filtered and evaporated to dryness to give the crude solid that is purified by a flash silica gel chromatography (eluent: 10% EtOAc in hexanes) to give 11.41 (1.0 g, 40%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3485-84-5, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2009/52078; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem