39603-24-2, A common heterocyclic compound, 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, molecular formula is C10H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a mixture of the protecting reagent RBr (0.2 mmol) and K2CO3 (0.138 g) in MeCN (10 mL), isatin (6) was added (0.147 g) at room temperature. After that, the reaction mixture was stirred 24 h at reflux. Then, the solvent was evaporated under vacuum, and the reaction crude was purified by column chromatography (SiO2, Hex:EtOAc 8:2), giving rise to the corresponding product 7.
The synthetic route of 39603-24-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Auria-Luna, Fernando; Marques-Lopez, Eugenia; Mohammadi, Somayeh; Heiran, Roghayeh; Herrera, Raquel P.; Molecules; vol. 20; 9; (2015); p. 15807 – 15826;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem