446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 446292-08-6
2 – ({(5S) -2-oxo-3- [4- (3-oxo-4-morpholinyl) phenyl] -1,3-oxazolidin-5- yl} methyl) -1,3 (2H) -dione (Formula 5) Were suspended in 150 ml of ethanol at 22 C ,16.2 g of a methylamine solution (concentration in water of 40%) was added.The reaction mixture is then heated to 60-63 C,The resulting solution was stirred at this temperature for 2 hours.55 C to 60 C After cooling,A total of 33.5 g of a hydrochloric acid solution (20% in water concentration) was added until the pH reached 2.7.After confirming that the crystallization of the product has commenced, After cooling,The precipitated reaction product was filtered under suction, washed with methanol and then dried to give 12.5 g of the desired product. (Yield: 80.5%)
Statistics shows that 446292-08-6 is playing an increasingly important role. we look forward to future research findings about (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione.
Reference:
Patent; IL DONG PHARMACEUTICAL CO., LTD.; LEE, Ki Yong; KWON, Jae Wook; SEO, Myeong Won; KANG, Jae Hoon; (15 pag.)KR2017/98031; (2017); A;,
Indoline – Wikipedia,
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