Continuously updated synthesis method about 70478-63-6

The chemical industry reduces the impact on the environment during synthesis 4-Bromoisoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.

70478-63-6, The chemical industry reduces the impact on the environment during synthesis 70478-63-6, name is 4-Bromoisoindoline-1,3-dione, I believe this compound will play a more active role in future production and life.

A mixture of 3-bromophthalimide (10.0 g, 44.2 mmol), potassium carbonate (12.2 g, 88.5 mmol) and potassium iodide (50 mg, 0.30 mmol) are stirred in 80 mL DMF for 15 min. The reaction mixture is cooled to 0 0C, methyl iodide (3.04 mL, 48.7 mmol) is added and the reaction mixture is stirred overnight at RT. The reaction mixture is filtered, the solids are washed with DMF and the filtrate is poured in water. The mixture is extracted with ethyl acetate and the combined organic phases are washed several times with water, dried over MgSO4 and concentrated in vacuo. Yield: 7.10 g.

The chemical industry reduces the impact on the environment during synthesis 4-Bromoisoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/112565; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem