496-12-8, Adding some certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8.
N-Nitrosoisoindoline 18: To a solution of isoindoline 45 in a mixture of 10 mL of acetic acid and 20 mL of water, an aqueous solution of NaNO2 (1.53 g, 22.2 mmol) in 10 mL of water was added at 0 C. The whole was stirred for 2 h, then extracted with CH2Cl2, and the organic layer was washed with 2 N aqueous NaOH, 0.5 N aqueous HCl, brine, and dried over sodium sulfate. The solvent was evaporated to give a residue, which was chromatographed (hexane: AcOEt = 1: 4 to 1: 3) to give 18 as an oil (1.32 g, 8.91 mmol, 45% from alpha,alpha-dibromo-o-xylene). Mp: 85-89 C (recrystallized from MeOH, grayish needles). MS ([M+H]+): 149. 1H NMR (400 MHz, CDCl3): delta 7.40-7.31 (4H, m), 5.63 (2H, s), 4.90 (2H, s).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 496-12-8.
Reference:
Article; Ohwada, Tomohiko; Ishikawa, Satoko; Mine, Yusuke; Inami, Keiko; Yanagimoto, Takahiro; Karaki, Fumika; Kabasawa, Yoji; Otani, Yuko; Mochizuki, Masataka; Bioorganic and Medicinal Chemistry; vol. 19; 8; (2011); p. 2726 – 2741;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem