Adding a certain compound to certain chemical reactions, such as: 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2058-72-2, 2058-72-2
General procedure: The reactions are conducted in a custom made, twelve membered carousal containing glass reaction chambered of 20 ml volume. To the stirred solution of 6-methylfuro[3,4-c]pyridine-3,4(1H,5H)-dione(200 mg, mmole) (1 equivalence) in ethanol (10 ml) , piperidine/pyrrolidine(1 equivalence) was added. To the stirring solution appropriateisatins (1.1 equivalence) were added under nitrogen atmosphere andthe resulting reaction mixture was refluxed at 80 C for 14 h (within which substantial amount of product precipitates from the reaction mixture). Then reaction mixture was cooled to room temperature and the supernatant was syringed off dissolved in ethyl acetate (10 ml) and washed with water. The organic layer was dried over Na2SO4, evaporated to obtain the crude which was purified by flash column chromatography with ethyl acetate/hexane as eluent.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-1-methylindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Luthra, Tania; Naga Lalitha; Uma; Sen, Subhabrata; Bioorganic and Medicinal Chemistry; vol. 26; 18; (2018); p. 4996 – 5005;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem