In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 317-20-4 as follows. 317-20-4
General procedure: To an aqueous mixture of 4-hydroxy-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one 3a (2 mmol), aldehyde 5 (2 mmol), malononitrile 4 (2 mmol) and piperidine (10 mol %) were added successively at room temperature under an open atmosphere with vigorous stirring. The progress of the reaction was monitored by thin layer chromatography. The precipitated solid was ltered, washed with water (10 mL) and ethanol (5 mL) and then with ether (3 mL). The product was dried under vacuum.
According to the analysis of related databases, 317-20-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Jayarajan, Ramasamy; Vasuki, Gnanasambandam; Tetrahedron Letters; vol. 53; 24; (2012); p. 3044 – 3048;,
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