4403-36-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4403-36-5 name is 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of p-bromophenethyl bromide (86.87 g, 0.33 mol),Thiourea (30.14 g, 0.396 mol),Anhydrous ethanol (120 ml) was placed in a round bottom flask,Mixed heating reflux,Until there is white precipitation,After filtration,Placed in a single mouth bottle by adding NaOH (135ml, 5M) aqueous solution,Reflow heating for five hours,After dilute hydrochloric acid is acidified,Separating the thiol layer,Dried over anhydrous sodium sulfate,20cm flavor fraction distillation column distillation (distillation range 146-148 ).Bromophenethyl bromide can be obtained by passing 2- (4′-bromophenyl) ethanol to hydrogen bromide.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, and friends who are interested can also refer to it.
Reference:
Patent; Beijing Institute of Printing; Wang, Wenguang; Yang, Mingcong; Pu, Jialing; (29 pag.)CN104961665; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem