Adding some certain compound to certain chemical reactions, such as: 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2436-29-5. 2436-29-5
To a solution of 2 (300 mg, 1.04 mmol) and 11a (317 mg, 1.56 mmol) in THF (30 mL) was added NH4OAc (802 mg, 10.4 mmol) in MeOH (30 mL). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was diluted with EtOAc and washed with a saturated aqueous solution of NaHCO3 and brine. The organic layer was dried over Na2SO4 and concentrated. The crude product was purified by column chromatography on silica gel eluting with 0-3% MeOH/CHCl3 to afford 2-{2-[5-(1,3-benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-2-yl]ethyl}-1H-isoindole-1,3(2H)-dione as a yellow solid (437 mg, 89%): MS (ESI) m/z 472 [M+H]+, 100%, 470 [M-H]-, 100%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-(1,3-Dioxoisoindolin-2-yl)propanal.
Reference:
Article; Amada, Hideaki; Sekiguchi, Yoshinori; Ono, Naoya; Koami, Takeshi; Takayama, Tetsuo; Yabuuchi, Tetsuya; Katakai, Hironori; Ikeda, Akiko; Aoki, Mari; Naruse, Takumi; Wada, Reiko; Nozoe, Akiko; Sato, Masakazu; Bioorganic and Medicinal Chemistry; vol. 20; 24; (2012); p. 7128 – 7138;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem