2058-74-4, These common heterocyclic compound, 2058-74-4, name is 1-Methylisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under an inert gas atmosphere, add a stir bar, 0.75 mmol of 1-methylisatin, 0.05 mmol of DBU, and 2 mL of acetonitrile to the autoclave, and then fill the autoclave with carbonyl sulfide gas of about 0.8MPa. After stirring for 24 hours at , the autoclave was opened, the reaction solution in the autoclave was dissolved in 2 ml of dichloromethane and transferred to a 50 ml round-bottomed single-neck flask, with (3¡Á2 ml) dichloromethane The autoclave was rinsed, and then the solvent was removed in vacuo to obtain a crude product.The crude product was separated and purified by column chromatography (eluent: dichloromethane).The yield was 91%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2058-74-4.
Reference:
Patent; Dalian University of Technology; Zhou Hui; Chen Wei; Lv Xiaobing; (10 pag.)CN111233741; (2020); A;,
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