2058-72-2, The chemical industry reduces the impact on the environment during synthesis 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, I believe this compound will play a more active role in future production and life.
General procedure: A mixture of N-methylisatin 1a (161 mg, 1 mmol, 1 equiv), phenylacetylene 2a (0.12 mL, 1 mmol, 1.2 equiv), 1-aminoanthraquinone (0.266 g, 1 mmol, 1.2 equiv) 3a, cuprous chloride (9.9 mg, 10 mol %), and copper(II) triflate (36.1 mg, 10 mol %) in dry toluene (4 mL) was refluxed at 120 C for 24 h under nitrogen atmosphere. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was cooled to room temperature, filtered through a pad of neutral alumina using ethyl acetate as a solvent. The solvent was evaporated in vacuo and the residue was chromatographed on neutral alumina using gradient elution of hexane/ethyl acetate as solvent to yield compounds 4a as pink powder, 183 mg, 39% yield and 5a as violet powder, 197 mg, 42% yield.
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1-methylindoline-2,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Article; Periyaraja, Somasundharam; Shanmugam, Ponnusamy; Mandal, Asit Baran; Senthil Kumar, Thiyagarajan; Ramamurthy, Perumal; Tetrahedron; vol. 69; 14; (2013); p. 2891 – 2899;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem