14192-26-8,Some common heterocyclic compound, 14192-26-8, name is Methyl 2-oxoindoline-6-carboxylate, molecular formula is C10H9NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the four 3000mL round-bottomed flask, fitted with mechanical stirring, reflux condenser, thermometer, nitrogen was added to a 1500mL round bottom flask of toluene, 240g6- methoxycarbonyl-2-oxo-indoline, chlorine 272g acetic anhydride, open stirring, temperature was raised to 80 ~ 90 , the reaction was stirred for 6 hours incubation, naturally fell off the heating 80 , 600ml of cyclohexane was added, and stirring was continued to cool down to room temperature, solid precipitated, suction filtered, the filter cake washed with cold ethanol and dried under vacuum to give 233.6g.Yield: 78%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-oxoindoline-6-carboxylate, its application will become more common.
Reference:
Patent; Nanjing Aide Kai Teng biological medicine limited liability company; Wang, Xuegen; He, Lingyun; Li, Xiaojing; Li, Yiwen; Yu, Yang; Guo, Liqin; (8 pag.)CN105418483; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem