These common heterocyclic compound, 52351-75-4, name is 6-Methoxyindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 52351-75-4
General procedure: 2-Acetoxy-4?-methoxyacetophenone(5b) (779 mg, 3.74 mmol) in EtOH (8.20 mL) was added to a solution of compound 4a (500 mg,3.40 mmol) in 10N NaOH (3.0 mL) and EtOH (800 L) at 85 C. After the mixture was stirred at 85 Cfor 1 h, H2O (10.0 mL) was added to the mixture at 0 C. The mixture was acidified to pH 1 with 1N HCl.The precipitate was collected by filtration and washed with H2O and EtOH to give the title compound 6bas a yellow solid (742 mg, 74%)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52351-75-4.
Reference:
Article; Yamamoto, Koki; Okazaki, Shiho; Ohno, Hiroaki; Matsuda, Fuko; Ohkura, Satoshi; Maeda, Kei-ichiro; Fujii, Nobutaka; Oishi, Shinya; Bioorganic and Medicinal Chemistry; vol. 24; 16; (2016); p. 3494 – 3500;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem