6326-79-0, name is 6-Bromoisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 6326-79-0
To a solution of compound 9 (10 g, 44.44 mmol) in EtOH (130 mL) was added a solution of hydroxylamine hydrochloride (4.61 g, 66.37 mmol) in H2O (20 mL), and the mixture was stirred at 80 C. for 12 h. The mixture was concentrated under reduced pressure and the solid formed was filtered, washed with cold water, and dried under high vacuum to afford 10.24 g (96%) of compound 10 as a blood-red solid. IR (KBr) numax. cm-1: 3336, 3330 (NH2), 3310 (OH), 3038 (Ar-H), 2920 (Alph-H), 1690 (C?O), 1612, 1515, 1414 (C?C), 1260 (C-N). 1H NMR (500 MHz, DMSO-d6) delta=7.02 (s, 1H, H-7); 7.20 (d, 1H, J=8.2 Hz, H-5); 7.84 (d, 1H, J=8.1 Hz, H-4); 10.83 (s, 1H, NH); 13.49 (s, 1H, OH); 13C NMR (125.7 MHz, DMSO-d6) delta=113.12 (aromatic-C), 115.50 (aromatic-C), 124.84 (aromatic-C), 128.46 (aromatic-C), 143.48 (aromatic-C), 144.02 (aromatic-C), 164.29, 167.12 (C?O). Calculated (%) for C8H5BrN2O2(239.95); C, 39.86; H, 2.09; N, 11.62. found (%); C, 39.80; H, 2.14; N, 11.58.
Statistics shows that 6326-79-0 is playing an increasingly important role. we look forward to future research findings about 6-Bromoisatin.
Reference:
Patent; King Fahd University of Petroleum and Minerals; King Abdulaziz City for Science and Technology; Ullah, Nisar; US8916704; (2014); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem