100487-74-9, The chemical industry reduces the impact on the environment during synthesis 100487-74-9, name is 6-Chloro-5-fluoroindolin-2-one, I believe this compound will play a more active role in future production and life.
General procedure: A reaction mixture of the proper substituted indolin-2-ones 6,aldehyde (1.2 eq.), and piperidine (0.1 eq.) in ethanol (1 mL/0.5 mmol oxindole) was refluxed for 3-5 h, under nitrogen atmosphere. After, the mixture was cooled and put on ice, where the product precipitated. The product was filtered in vacuum with cold ethanol [10,14-17]. Finally, the product was placed in the vacuum desiccators to give the expected compound. The indolin-2-ones 3e was generated through substituted isatin in the presence of hydrazine monohydrate and ethylene glycerol, under reflux [18].
The chemical industry reduces the impact on the environment during synthesis 6-Chloro-5-fluoroindolin-2-one. I believe this compound will play a more active role in future production and life.
Reference:
Article; Nunes, Rute C.; Ribeiro, Carlos J.A.; Monteiro, Angelo; Rodrigues, Cecilia M.P.; Amaral, Joana D.; Santos, Maria M.M.; European Journal of Medicinal Chemistry; vol. 139; (2017); p. 168 – 179;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem