In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 2058-72-2
General procedure: A mixture of substituted isatin 4a-v (1 mmol), sarcosine 5 (1 mmol) and 3-(1H-indol-3-yl)-3-oxo-2-(2-oxoindolin-3-ylidene)propanenitrile 6 (1 mmol) were refluxed in ethanol (5 mL). After completion of the reaction as evidenced by TLC analysis, the reaction mixture was poured into ice-water, the resulting solid was filtered off and purified by column chromatography using ethyl acetate/petroleum ether (6:4) as an eluent to afford pure spirooxindoles 7a-v.
The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Arun; Bhaskar; Balachandran; Ignacimuthu; Perumal; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1839 – 1845;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem