A common compound: 4403-36-5, name is 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 4403-36-5
To a solution of 2-{3-exo-[(R)-1-((S)-2-methyl-propane-2-sulfinylamino)-2-(2,4,5-trifluoro- phenyO-ethylJ-beta-aza-bicyclop^.ijoctane-beta-sulfonylJ-ethylamine (100 mg, 0.202 mmol) in dichloromethane / 2N NaOH (2 mL, 1/1) are 2-phtalimidoethanesulfonyl chloride (167 mg, 0.605 mmol). The resulting solution is stirred at 500C during 2h before extraction and evaporation of organic phase to yield the crude compound. It is purified by preparative HPLC (Column Waters C18 ODB 5mum 19×50, Gradient: 0-2.5 min 5% ACN, 2.5-12.5 min 5-100% ACN, 12.5-15 min 100% ACN) to yield title compound. MS: 734 [M+H]+HPLC (Zorbax SB C18, 2min method (0-0.8min 10-95%ACN, 0.8-1.5min 95%ACN, 1.5- 1.6min 95-10%ACN, 1.6-2min 10%ACN): 1.43 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4403-36-5, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/115821; (2007); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem