1914-02-9, A common compound: 1914-02-9, name is 3,3-Dimethylindoline, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Step 4. 3,3-dimethyl-2,3-dihydro-1 /-/-indole-6-sulfonic acidA mixture of 3, 3-dimethyl-2,3-dihydro-1 /-/-indole (16.0 g, 109 mmol) in fuming sulphuric acid (60 mL) was stirred at rt for 45 min. The reaction was then heated to 135 C for 1 h. After cooling the solution was poured into ice water, cooled to -50 C and allowed to stand for 2 h. The resultant precipitate was collected by filtration to give 3,3- dimethyl-2,3-dihydro-1 H-indole-6-sulfonic acid (7 g, 28 %). MS (m/z) 228.0 (M+H)+. 1H NMR (400 MHz, DMSO-d6) delta ppm 1 .31 (s, 6 H) 3.52 (s, 2 H) 7.40 (d, J=7.94 Hz, 1 H) 7.58 (s, 1 H) 7.64 (dd, J=7.83, 1 .43 Hz, 1 H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3-Dimethylindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE LLC; KALLANDER, Lara, S.; LAWHORN, Brian, Griffin; PHILIP, Joanne; ZHAO, Yongdong; WO2011/88027; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem