3416-57-7, A common heterocyclic compound, 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione, molecular formula is C11H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0317] To a solution of 2-(2-oxopropyl)isoindoline-1,3-dione (1 g, 4.9 mmol) in 20 mL ofDMF-DMA was added some of 4A molecular sieve. The reaction mixture was stirred at 100 Cunder N2 for 15 hr. After cooling down toRT, the mixture was filtered and collected 600 mg(47.5%) of crude (E)-2-(4-(dimethylamino)-2-oxobut-3-enyl) isoindoline-1,3-dione as a solid.MS (ESI) m/e [M+It 259.1.
The synthetic route of 3416-57-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GUO, Yunhang; BEIGENE, LTD.; WANG, Zhiwei; WO2014/173289; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem