These common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 317-20-4
Add in a 25 mL round bottom flask(E) -N-4-chlorobenzyl) -N- (4-methylbenzyl) -2-nitroethylene-1,1-diamine(1 mmol)And 7-fluoroindoline-2,3-dione (1.1 mmol), toluene (15 ml) and acetic acid (1 mlMole) was heated under magnetic stirring to 110 C for 14 hours. TLC monitoring reaction until the point of complete disappearance of raw materials, the reaction solutionThe mixture was extracted with 50 ml of ethyl acetate and 50 ml of saturated aqueous sodium chloride. The organic layer was dried over anhydrous magnesium sulfateDry, with petroleum ether / ethyl acetate = 7: 1 eluent silica gel column was dried to give a yellow solidThe product N- (4-chlorobenzyl) -2-(4-chlorobenzylamino) -7-fluoro-3-nitroquinoline-4-carboxamide (compound 30) in 75% yield.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 317-20-4.
Reference:
Patent; Yunnan University; Yan Shengjiao; Wang Baoqu; Lin Jun; (25 pag.)CN107522659; (2017); A;,
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