The chemical industry reduces the impact on the environment during synthesis 324-03-8, name is 6-Fluoroindoline-2,3-dione, I believe this compound will play a more active role in future production and life. 324-03-8
General Procedure: To a solution of 4-chloro isatin (500 mg, 2.75 mmol) in acetone (5 mL) was added diethylamine (314 muL, 3.02 mmol) at room temperature. The mixture was heated to 50 oC for 14 hours with magnetic stirring and then concentrated under reduced pressure. The resulting alcohol intermediate was triturated in diethyl ether with sonication, filtered and the resulting white solids were used without further purification. To a solution of the alcohol intermediate dissolved in ethanol (3 mL) was added concentrated hydrochloric acid (1 mL). The mixture was stirred at room temperature for 14 hours and then quenched with a solution of saturated sodium bicarbonate (5 mL). The mixture was extracted with dichloromethane (20 mL), concentrated and purified by silica gel flash chromatography using a gradient of 30 – 80% ethyl acetate in hexanes to afford the target compound 10 as a yellow solid.
The chemical industry reduces the impact on the environment during synthesis 324-03-8. I believe this compound will play a more active role in future production and life.
Reference:
Conference Paper; Kloeck, Cornelius; Jin, Xi; Choi, Kihang; Khosla, Chaitan; Madrid, Peter B.; Spencer, Andrew; Raimundo, Brian C.; Boardman, Paul; Lanza, Guido; Griffin, John H.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 9; (2011); p. 2692 – 2696;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem