Adding some certain compound to certain chemical reactions, such as: 20870-78-4, name is 5-Bromoindolin-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20870-78-4. 20870-78-4
Description 3:(Z)-3-{(1H-Pyrrol-2-yl)methylene)-5-bromoindolin-2-oneIn a 35 ml microwave tube were placed 5-bromo-1,3-dihydro-2H-indol-2-one (1 mmol), pyrrole-2-carbaldehyde (1.2 mmol), piperidine (2 drops), ethanol (10 ml) and a magnetic stir bar. The vessel was sealed with a septum and placed in the microwave cavity. Initial microwave irradiation of 200 W was used, the temperature being ramped from RT to 150 C. Once 150 C was reached the reaction vessel was held at this temperature for 30 min by moderation of the initial microwave power. After cooling, solvent was removed in vacuo and ethyl acetate was added to the reaction mixture. The precipitate was collected by filtration and washed with ethyl acetate (2x 10 ml) to afford a yellow-brown solid. The results set out below identify the product as the title compound D3.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Bromoindolin-2-one.
Reference:
Patent; University of Greenwich; SPENCER, John; WO2012/25726; (2012); A1;,
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