222036-66-0, The chemical industry reduces the impact on the environment during synthesis 222036-66-0, name is 5-Aminoisoindolin-1-one, I believe this compound will play a more active role in future production and life.
To a solution of 5-aminoisoindolin-1-one (2.96 g, 20 mmol) in chloroform (50 mL) was added N-chlorosuccinimide (2.67 g, 20 mmol), and stirred under reflux for 2 hours. The resulting mixture was evaporated, concerntrated and then purified by silica gel column chromatography to give 4-chloro-5-aminoisoindolin-1-one (2.58 g). Yield: 70percent. MS m/z[ESI]: 183.0[M+1].
The chemical industry reduces the impact on the environment during synthesis 5-Aminoisoindolin-1-one. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Centaurus BioPharma Co., Ltd.; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; Lianyungang Runzhong Pharmaceutical Co., Ltd.; XU, Xinhe; SHEN, Yu; XIAO, Dengming; LUO, Hong; PENG, Yong; HAN, Yongxin; ZHANG, Aiming; YANG, Ling; (51 pag.)EP3257857; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem