496-12-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 496-12-8 as follows.
2) Triethylamine (0.33 ml, 2.37 mmol) and isoindoline (0.27 ml, 2.38 mmol) were added in turn to a solution of methyl ester of 5-chloro-2-trifluoromethanesulfonyloxy-3-nitrobenzoic acid (820 mg, 2.25 mmol) in dimethyl sulfoxide (5 ml) and the mixture was stirred at room temperature for 1 hr. The reaction mixture was cooled with ice and ice water (50 ml) was added thereto. The mixture was stirred and the precipitates were filtered, washed with water and dried. The resultant yellow crystals were purified by column chromatography on silica gel (n-hexane/ethyl acetate=15) to give methyl ester of 5-chloro-2-(1,2,3,4-tetrahydroisoquinolinio)-3-nitrobenzoic acid (608 mg, 81%) as yellow crystals. m.p.: 114-115 C.; IR (Nujol) : 1743, 1705, 1603, 1589, 1529, 1503 cm-1; APCI-MS m/z: 333[M+H]+.
According to the analysis of related databases, Isoindoline, the application of this compound in the production field has become more and more popular.
Reference:
Patent; J-Pharma Co., Ltd.; ENDOU, Hitoshi; WEMPE, Michael F.; PEYRON, Jean-Francois; ANZAI, Naohiko; JUTABHA, Promsuk; (83 pag.)EP2959918; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem