675109-26-9, name is 6-Bromoisoindolin-1-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 675109-26-9
To a solution of 6-bromoisoindolin-l-one (2.418 g, 11.4 mmol) in DMF (57 mL) at 0 C. was added NaH (0.547 g, 13.68 mmol). The resulting dark suspension was allowed to stir for 60 min before addition of PMBC1 (1.86 mL, 13.68 mmol). The reaction was then allowed to stir at room temperature for 3 hours. The crude was diluted by EtOAc, washed with water and brine. The organic layers were dried over Na2SO4 and concentrated. The residue was purified by chromatography on silica gel using 0->50% EtOAc in hexanes to afford 3.18 g yellow solid as compound 2 (84% yield). 1H NMR (400 MHz, Chloroform-d) delta8.04 (d, J=1.9 Hz, 1H), 7.65 (dd, J=8.0, 1.9 Hz, 1H), 7.25 (d, J=8.6 Hz, 2H), 6.89 (d, J=8.6 Hz, 2H), 4.75 (s, 2H), 4.22 (s, 2H), 3.82 (s, 3H).
Statistics shows that 675109-26-9 is playing an increasingly important role. we look forward to future research findings about 6-Bromoisoindolin-1-one.
Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; Wang, Guoqiang; He, Jing; Wang, Bin; Shen, Ruichao; Granger, Brett; Or, Yat Sun; US2019/62310; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem