2518-24-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2518-24-3 name is 4-Aminoisoindoline-1,3-dione, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-Aminophthalimide (2.00 g, 12.3 mmol) was dissolved in methanol (200 mL), and the solution was added with N-bromosuccinimide (2.19 g, 12.3 mmol), followed by stirring at room temperature for 50 minutes. The obtained solid was collected by filtration and washed with methanol to obtain 3-amino-6-bromophthalimide (2.21 g, yield 74%). APCI-MS m/z: 241 [M-H]-; 1H-NMR (DMSO-d6)delta(ppm): 6.53 (br s, 2H), 6.88 (d, J = 8.9 Hz, 1H), 7.49 (d, J = 8.9 Hz, 1H), 11.07 (br s, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Aminoisoindoline-1,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem