15362-40-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15362-40-0 as follows.
To the four-necked flask was added 668 ml of water and then compound IV (233 g, 0.84 mol), potassium hydroxide (94.3 g,1.68 mol) and the temperature was raised to 100 C for 5 hours. Cool to 60 ~ 65 C, vacuum filter, add a small amount of water, filter cake at 85 CAfter dissolving in water,Join eta SO4 (27 0 g, 1.6 8mo 1) aqueous solution at 8 5 C for 1 hour, cooled and filtered to give a white solid494.0 g (Compound I: diclofenac zinc) in a yield of 90%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 15362-40-0, and friends who are interested can also refer to it.
Reference:
Patent; Jilin University; Liaoyuan Yinying Pharmaceutical Co., Ltd.; Li Guiying; Wang Zhaokun; Li Shumei; Peng Xiaojuan; Jin Xingtong; (8 pag.)CN106905178; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem