480-91-1, A common heterocyclic compound, 480-91-1, name is Isoindolin-1-one, molecular formula is C8H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of isoindolin-1-one (1.00 g, 7.51 mmol) in freshly-distilled THF (25 mL) was added slowly to a suspension of sodium hydride (450 mg, 11.26 mmol, freshly washed with hexane) in THF (25 mL) under N2 at 0 C and stirring was continued (30 min). To the reaction mixture was slowly added ethyl bromoacetate (1.24 mL, 11.26 mmol) and the resulting reaction mixture was allowed to stir at room temperature (16 h). The reaction mixture was quenched with methanol and concentrated. The obtained crude residue was further purified by gravity column chromatography (hexane/ethyl acetate, 2:1) provided pure 1 as an off-white solid (1.39 g, 78%); mp = 77-79C (Lit. mp = 78-80 C)1. 1H NMR (400 MHz, CDCl3) delta 7.87-7.85 (d, J = 7.6 Hz, 1H), 7.57-7.53 (m, 1H), 7.48-7.44 (m, 2H), 4.518 (s, 2H), 4.39 (s, 2H), 4.22 (q, J = 6.8 Hz, 2H), 1.28 (t, J = 6.8 Hz, 3H) ppm. The spectroscopic data was consistent with that previously reported.1
The synthetic route of 480-91-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Patil, Pravin C.; Luzzio, Frederick A.; Ronnebaum, Jarrid M.; Tetrahedron Letters; vol. 58; 38; (2017); p. 3730 – 3733;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem