3335-98-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3335-98-6 name is 1-Phenyloxindole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A mixture of t-BuOK (1.63 g, 14.5 mmol) in EtOH (5.0 mL) was heated at 80 oC. Oxindole (10.0 mmol) was added, followed immediately by ethyl formate (1.09 mL, 13.5 mmol). Then, the reaction mixture was heated at 80 C for 5 min, and was cooled to 25 C. Crushed ice and H2O were added, then the mixture was acidified with 3 N HCl to pH = 3. The crude product was filtered and washed with water. Recrystallization from MeOH gave the pure product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Phenyloxindole, and friends who are interested can also refer to it.
Reference:
Article; Liu, Yin-Li; Xu, Xiu-Hua; Qing, Feng-Ling; Tetrahedron; vol. 74; 40; (2018); p. 5827 – 5832;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem