14192-26-8, These common heterocyclic compound, 14192-26-8, name is Methyl 2-oxoindoline-6-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 2 – oxo indoline -6 – methyl formate (5g, 0.026 muM), acetic anhydride (20 ml) and the original benzoic acid triethyl ester (29.1g, 0 . 13 muM) are added to a reaction flask, 130 C reaction 6h. The completion of the reaction, the reaction is cooled down to room temperature, filtered, the filter cake is petroleum ether washing, drying, be picture and the solid 7.1g, yield is 75%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 14192-26-8.
Reference:
Patent; Shenyang Pharmaceutical University; Qin Mingze; Gong Ping; Zhang Haotian; Zhao Yanfang; (39 pag.)CN106565682; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem