A common heterocyclic compound, 52351-75-4, name is 6-Methoxyindoline-2,3-dione, molecular formula is C9H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 52351-75-4.
A mixture of 6-methoxyisatin (0.18g, 0.001mol) in Anhyd. ethanol (2ml) and thiosemicarbazide(0.1g, 0.0011 mol) in a mixture of water (2 ml) andglacial acetic acid (0.5 ml) was irradiated undermicrowave irradiation at 560W for 5-minutes. Ayellow coloured solid formed during irradiation. Thesolid was filtered, washed well with water andcrystallized from ethanol-DMF furnishing yellowcrystals. Yield 0.247g (95%), m.p. 265OC.[Found :N, 22.68, S, 12.62. C10H10N4O2S requires N, 22.40;S, 12.80%]; IR: 825, 860 (1, 2, 4-trisubstitutedbenzene ring), 1115 (C=S), 1125 & 1370 (C-O-Cstretching), 1620 (C=N), 1700 (C=O), 3200, 3280,3400 (NH, NH2).
The synthetic route of 6-Methoxyindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Singh, Ravinder; Oriental Journal of Chemistry; vol. 31; 1; (2015); p. 509 – 513;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem