118-29-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118-29-6 as follows.
To a stirred solution of 2,3,3,-trimethylindolenine (20 g, 126 mmol) in concentrated sulphuric acid (100 ml) at ambient temperature was added portionwise N-hydroxymethylphthalimide (20 g, 114 mmol). After 70 hours the reaction mixture was poured onto ice and made basic with concentrated ammonium hydroxide. The resulting precipitate was filtered and dried. The product was obtained as a yellow solid (34.84 g, 87%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 118-29-6, and friends who are interested can also refer to it.
Reference:
Patent; Carnegie Mellon University; US2003/224391; (2003); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem