A common heterocyclic compound, 324-03-8, name is 6-Fluoroindoline-2,3-dione, molecular formula is C8H4FNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 324-03-8.
General procedure: The typical process for preparation of isatin-DHEAconjugates 4a-e is shown as following: To a solution of dehydroepiandrosterone-17hydrazone 3 (0.3 g, 1 mmol) inethanol (15 mL) was added the equal amounts of substituted isatin (1 mmol), which werestirred at ambient temperature or 50 oC and detected by thin-layerchromatography. Then the solution was concentrated, and the condensation product 4a-eseparated out on cooling (0-4 oC) and was recrystallized from ethanol. All the compounds were characterized by ESI-MS, 1HNMR spectroscopic data
The synthetic route of 6-Fluoroindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ke, Shaoyong; Shi, Liqiao; Yang, Ziwen; Bioorganic and Medicinal Chemistry Letters; vol. 25; 20; (2015); p. 4628 – 4631;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem