222036-66-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 222036-66-0, name is 5-Aminoisoindolin-1-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 4: 5-f(2-mS,2SV2-ri-(5-chloropyrimidin-2-vnpiperidin-4- yllcyclorhororhoyl}efoyl)amino1isoindolin- 1 -one2-{(lS,2R)-2-[l-(5-chloropyrimidin-2-yl)piperidin-4-yl]cycIopropyl}ethyl 4- methylbenzenesulfonate from step 1 of Example 5 (100 mg, 0.23 mmol) was dissolved in sulfolane and 5-aminoisoindolin-1-one (68 mg, 0.46 mmol) from step 3 of this example added. The mixture was at stirred 110 ¡ãC for 3 and at 120 ¡ãC for 2 hours.The mixture was cooled to RT, diluted with 4:1 water: saturated sodium bicarbonate (40 ml), extracted with EtOAc (3×30 ml), the organic fractions combined, washed with brine, dried over Na2SO4, filtered, the volatiles removed in vacuum. The product was purified by chromatography on SiO2 eluting with 80percent acetone : hexanes to give the titled compound. LRMS calc: 411.18; obs: 412.08 (M+l).
The synthetic route of 5-Aminoisoindolin-1-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WOOD, Harold, B.; ADAMS, Alan, D.; SZEWCZYK, Jason, W.; ZHANG, Yong; YANG, Meng; WO2011/19538; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem