2436-29-5, The chemical industry reduces the impact on the environment during synthesis 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, I believe this compound will play a more active role in future production and life.
Aldehyde 9 (6.54 g, 32.2 mmol) was dissolved in propan-2-ol (60 ml). 37% aq.formaldehyde (2.64 ml, 35.4 mmol), pyrrolidine (0.27 ml, 3.22 mmol) and propionic acid (0.24 ml, 3.22 mmol) were added and the reaction mixture was stirred at 45 C for 24 h. The reaction mixture was transferred to a separating funnel with sulfate buffer (100 ml) and extracted with EtOAc (3 ¡Á 40 ml). The combined organic phases were washed with NaHCO3 (100 ml), and brine (100 ml), dried (Na2SO4), filtered and concentrated in vacuo to give alkene 12 (3.78 g, 55%) as a white amorphous powderthat required no further purification.
The chemical industry reduces the impact on the environment during synthesis 3-(1,3-Dioxoisoindolin-2-yl)propanal. I believe this compound will play a more active role in future production and life.
Reference:
Article; Domeyer, Svenja; Bjerregaard, Mark; Johansson, Henrik; Pedersen, Daniel Sejer; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 644 – 647;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem