In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181140-34-1 as follows. 181140-34-1
To a solution of 2-[(2f?)-2-oxiranylmethyl]-1 H-isoindole-1 ,3(2H)-dione (2.Og, 10.0 mmol) in isopropyl alcohol (40 ml_) were added 2-chloro-4-fluorobenzenesulfonamide (2.51 g, 12.0 mmol) and pyridine (0.16 g, 2.0 mmol). The reaction mixture was refluxed for overnight. Solvent was removed and residue was purified by flash column chromatography on silica gel (Biotage, 0.5%-2% MeOH/CH2CI2) to provide the title compound (2.64 g, 55.0%).
According to the analysis of related databases, 181140-34-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/29210; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem