Adding some certain compound to certain chemical reactions, such as: 3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3416-57-7. 3416-57-7
A 20-mL Schlenk replaced with argon was cooled to 0 C. in an ice bath, and methanol (5 mL), methylene chloride (5 mL), phthalsuccinimidyl acetone 2 (MW: 203.19) (406.4 mg), (R)-1-phenylethylamine (MW: 121.18) (283.6 mL), and formic acid (MW: 46.03) (226.4 mL) were added. (S)-Catalyst 1 (MW: 562.15) (5.65 mg) was added thereto, and the mixture was stirred with heating at 30 C. for 16 h. After 16 h, 1H-NMR spectrum was measured to confirm the generation of desired product with a conversion rate of 63%. Regarding the diastereomer ratio, generation of a single diastereomer (>99% de) was confirmed in H-NMR spectrum in deuterated chloroform.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2-(2-Oxopropyl)isoindoline-1,3-dione.
Reference:
Patent; Kanto Kagaku Kabushiki Kaisha; Watanabe, Masahito; Takemoto, Toshihide; Tanaka, Kouichi; Murata, Kunihiko; (36 pag.)US2016/60282; (2016); A1;,
Indoline – Wikipedia,
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