1168150-46-6, name is (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 1168150-46-6
(3) Preparation of methyl (Z)-3-((1-(2-(dimethylamino) acetyl)indolin-5-ylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate and its hydrochloride1-(2-(dimethylamino) acetyl)-5-aminoindoline (0.082g, 0.3mmol) and methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate (0.086g, 0.28mmol) was added to MeOH (2ml). The resulting mixture was heated to 70 C and kept for 7 hours. After being cooled naturally, the mixture was filtered by suction. The filtrate was dried to produce a yellow solid (61mg) in a yield of 35.4%.Methanol (10ml) was added to a concentrated hydrochloric acid (1ml). The above crude product was added to the resulting solution. The mixture was stirred at room temperature for 2 hours, and filtered by suction. The filtrate was dried in vacuum to produce methyl (Z)-3-((1-(2-(dimethylamino) acetyl)indolin-5-ylamino)(phenyl)methylene)-2oxoindoline-6-carboxylate hydrochloride (68mg) as a yellow solid. Formula: C29H28N4O4; MW: 496.2; Mass Spectrum (m/e): 497.3 (M+1) 1H NMR (400MHz; hydrochloride, DMSO-d6, deltappm) ? 12.16 (s, 1H), 10.96 (s, 1H), 9.77 (br. s., 1H), 7.79 (d, J = 8.8 1H), 7.56 (m, 3H), 7.45 (m, 2H), 7.26 (s, 1H), 7.17(m, 1H), 6.88 (s, 1H), 6.74 (s, 1H), 5.81(d, J = 8.4, 1H), 4.25 (m, 2H), 3.96(m, 2H), 3.76 (s, 3H), 3.04 (m, 2H), 2.83 (m, 6H).
Statistics shows that 1168150-46-6 is playing an increasingly important role. we look forward to future research findings about (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate.
Reference:
Patent; KBP Biosciences Co., Ltd.; LO, Hoyin; WANG, Aichen; ZHANG, Qian; EP2930167; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem