These common heterocyclic compound, 2913-97-5, name is N-(2-Oxoethyl)phthalimide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2913-97-5
General method for the synthesis of compound 7: Phthalimidoacetaldehyde 4 (0.378 g, 2 mmol) was dissolved in 6 mL of acetonitrile. To this solution added 6-bromoindole 5a (0.780 g, 2 mmol), barbituric acid 6 (0.312 g, 2 mmol), and catalytic amount of D-L-Proline under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 24 h. The resulting suspension was filtered and the precipitate was washed with acetonitrile (2 .x. 50 mL) to obtain a white compound 7a. The product 7a was obtained in a 95percent yield (1.00 g), m.p 107-108 ¡ãC. 1H NMR (300 MHz, CDCl3): delta 2.84 (s, 3H), 3.05 (s, 3H), 3.86 (d, 1H), 4.33 (m,1H), 4.70 (d, 2H), 7.05-8.01 (m, 8H), 8.23 (br s, 1H). Similarly compound 7b-c were synthesised and characterised.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2913-97-5.
Reference:
Article; Seetham Naidu; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 53; 4; (2012); p. 426 – 428;,
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