446292-07-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 446292-07-5, name is (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.
A compound having the structure of formula (I) (106.76 g, 270 mmol) was suspended in 4000 ml of anhydrous tetrahydrofuran(About 40ml / g), stir, gradually heated to 50 C, maintained at 50 C,A solution of triphosgene (80.2 g, 270 mmol) in tetrahydrofuran (268 ml) was added dropwise over 30 minutes,Heated to 64 C reflux, about 10 minutes after the clarification, about 1 hour and precipitation of solid, let cool to room temperature,The filter cake was washed with absolute ethanol (120 ml * 3 times) and air dried at 45 C to give 111.4 g of a compound having the structure of formula (II) in a yield of 97.9%
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Reference:
Patent; SHENZHEN HYBIO PHARMACEUTICAL CO., LTD.; YUAN, HUIXING; XIAO, QING; LI, GUOTAO; MA, YAPING; YUAN, JIANCHENG; (21 pag.)CN104016975; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem